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1

Increased MTH1-specific 8-oxodGTPase activity is a hallmark of cancer in colon, lung and pancreatic tissue

McPherson, Lisa A., Troccoli, Clara I., Ji, Debin, Bowles, Annie E., Gardiner, Makelle L., Mohsen, Michael G., Nagathihalli, Nagaraj S., Nguyen, Dao M., Robbins, David J., Merchant, Nipun B., Kool, Er

Journal:

Year:

2019

Language:

english

File:

PDF, 585 KB

english, 2019

2

Stroma secreted IL6 selects for âstem-likeâ population and alters pancreatic tumor microenvironment by reprogramming metabolic pathways

Kesh, Kousik, Garrido, Vanessa T., Dosch, Austin, Durden, Brittany, Gupta, Vineet K., Sharma, Nikita S., Lyle, Michael, Nagathihalli, Nagaraj, Merchant, Nipun, Saluja, Ashok, Banerjee, Sulagna

Journal:

Cell Death and Disease

Year:

2020

File:

PDF, 2.48 MB

2020

3

Diallyl disulfide causes caspase-dependent apoptosis in human cancer cells through a Bax-triggered mitochondrial pathway

Nagathihalli S. Nagaraj, Kandangath R. Anilakumar, Om V. Singh

Journal:

The Journal of Nutritional Biochemistry

Year:

2010

Language:

english

File:

PDF, 768 KB

english, 2010

4

Cathepsin B mediates TRAIL-induced apoptosis in oral cancer cells

Nagathihalli S. Nagaraj, Nadarajah Vigneswaran, Wolfgang Zacharias

Journal:

Journal of Cancer Research and Clinical Oncology

Year:

2006

Language:

english

File:

PDF, 623 KB

english, 2006

5

Hypoxia inhibits TRAIL-induced tumor cell apoptosis: Involvement of lysosomal cathepsins

Nagathihalli S. Nagaraj, Nadarajah Vigneswaran, Wolfgang Zacharias

Journal:

Year:

2007

Language:

english

File:

PDF, 729 KB

english, 2007

6

Proteomics: a strategy to understand the novel targets in protein misfolding and cancer therapy

Nagaraj, Nagathihalli S, Singh, Om V, Merchant, Nipun B

Journal:

Expert Review of Proteomics

Year:

2010

Language:

english

File:

PDF, 497 KB

english, 2010

7

Using Genomics to Develop Novel Antibacterial Therapeutics

Nagaraj, Nagathihalli S., Singh, Om V.

Journal:

Critical Reviews in Microbiology

Year:

2010

Language:

english

File:

PDF, 750 KB

english, 2010

8

RAD51 as a potential biomarker and therapeutic target for pancreatic cancer

Nagaraj S. Nagathihalli, Ganesh Nagaraju

Journal:

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

Year:

2011

Language:

english

File:

PDF, 366 KB

english, 2011

9

Smoking Induces Epithelial-to-Mesenchymal Transition in Non-Small Cell Lung Cancer through HDAC-Mediated Downregulation of E-Cadherin

Nagathihalli, N. S., Massion, P. P., Gonzalez, A. L., Lu, P., Datta, P. K.

Journal:

Molecular Cancer Therapeutics

Year:

2012

Language:

english

File:

PDF, 1.84 MB

english, 2012

10

Cathepsin B promotes both motility and invasiveness of oral carcinoma cells

Nalinie S. Wickramasinghe, Nagathihalli S. Nagaraj, Nadarajah Vigneswaran, Wolfgang Zacharias

Journal:

Archives of Biochemistry and Biophysics

Year:

2005

Language:

english

File:

PDF, 518 KB

english, 2005

11

Amphiregulin is the Key Ligand Associated with Src-Dependent EGFR Activation

V.K. Yarlagadda, J.A. Castellanos, N.S. Nagathihalli, Y. Beesetty, M. Kay Washington, R. Coffey, N.B. Merchant

Journal:

Journal of Surgical Research

Year:

2012

Language:

english

File:

PDF, 54 KB

english, 2012

12

Silencing of cystatin M in metastatic oral cancer cell line MDA-686Ln by siRNA increases cysteine proteinases and legumain activities, cell proliferation and in vitro invasion

Nadarajah Vigneswaran, Jean Wu, Nagathihalli Nagaraj, Rohaizah James, Patrick Zeeuwen, Wolfgang Zacharias

Journal:

Year:

2006

Language:

english

File:

PDF, 396 KB

english, 2006

13

Cigarette smoke condensate induces cytochromes P450 and aldo-keto reductases in oral cancer cells

Nagathihalli S. Nagaraj, Simone Beckers, John K. Mensah, Sabine Waigel, Nadarajah Vigneswaran, Wolfgang Zacharias

Journal:

Toxicology Letters

Year:

2006

Language:

english

File:

PDF, 716 KB

english, 2006

14

Cigarette smoke condensate increases cathepsin-mediated invasiveness of oral carcinoma cells

Nagathihalli S. Nagaraj, Wolfgang Zacharias

Journal:

Toxicology Letters

Year:

2007

Language:

english

File:

PDF, 723 KB

english, 2007

15

Hypoxia-mediated apoptosis in oral carcinoma cells occursviatwo independent pathways

Nagathihalli S Nagaraj, Nadarajah Vigneswaran, Wolfgang Zacharias

Journal:

Molecular Cancer

Year:

2004

Language:

english

File:

PDF, 4.96 MB

english, 2004

16

Targeting the transforming growth factor-β signaling pathway in human cancer

Nagaraj, Nagathihalli S, Datta, Pran K

Journal:

Expert Opinion on Investigational Drugs

Year:

2010

Language:

english

File:

PDF, 440 KB

english, 2010

17

Screening for coronary heart disease and diabetes risk in a dental setting

Kalladka, Mythili, Greenberg, Barbara L., Padmashree, Shreenivasa Murthy, Venkateshaiah, Nagathihally Thirumalegowda, Yalsangi, Shilpa, Raghunandan, Bangalore Nagarajachar, Glick, Michael

Journal:

International Journal of Public Health

Year:

2014

Language:

english

File:

PDF, 260 KB

english, 2014

18

Pancreatic Stellate Cell Secreted IL-6 Mediates STAT3 Dependent Tumorigenesis

Castellanos, J.A., Beesetty, Y., Ambrose, M., Nagathihalli, N., Merchant, N.B.

Journal:

Journal of Surgical Research

Year:

2014

Language:

english

File:

PDF, 77 KB

english, 2014

19

Cross-talk between STAT3 and MAPK signaling in pancreatic cancer

Nagathihalli, N., Beesetty, Y., Shi, C., Merchant, N.

Journal:

Year:

2013

Language:

english

File:

PDF, 41 KB

english, 2013

20

STAT3 Inhibition Attenuates Chemoresistance and Enhances Drug Delivery in Pancreatic Cancer

Castellanos, J.A., Nagathihalli, N., Beesetty, Y., Reyzer, M., Shi, C., Caprioli, R.M., Merchant, N.B.

Journal:

Journal of Surgical Research

Year:

2013

Language:

english

File:

PDF, 75 KB

english, 2013

21

Integrating genomics and proteomics-oriented biomarkers to comprehend lung cancer

Nagaraj, Nagathihalli S, Singh, Om V

Journal:

Expert Opinion on Medical Diagnostics

Year:

2009

Language:

english

File:

PDF, 351 KB

english, 2009

22

Smoking Attenuates Transforming Growth Factor- -Mediated Tumor Suppression Function through Downregulation of Smad3 in Lung Cancer

Samanta, D., Gonzalez, A. L., Nagathihalli, N., Ye, F., Carbone, D. P., Datta, P. K.

Journal:

Cancer Prevention Research

Year:

2012

Language:

english

File:

PDF, 1.78 MB

english, 2012

23

Novel Mechanistic Insights into Ectodomain Shedding of EGFR Ligands Amphiregulin and TGF- : Impact on Gastrointestinal Cancers Driven by Secondary Bile Acids

Nagathihalli, N. S., Beesetty, Y., Lee, W., Washington, M. K., Chen, X., Lockhart, A. C., Merchant, N. B.

Journal:

Cancer Research

Year:

2014

Language:

english

File:

PDF, 1.90 MB

english, 2014

24

STAT3 Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer

Nagathihalli, Nagaraj S., Castellanos, Jason A., Shi, Chanjuan, Beesetty, Yugandhar, Reyzer, Michelle L., Caprioli, Richard, Chen, Xi, Walsh, Alex J., Skala, Melissa C., Moses, Harold L., Merchant, Ni

Journal:

Gastroenterology

Year:

2015

Language:

english

File:

PDF, 4.70 MB

english, 2015

25

Differential susceptibility of metastatic and primary oral cancer cells to TRAIL-induced apoptosis

Vigneswaran, Nadarajah, Wu, Jean, Nagaraj, Nagathihalli, Adler-Storthz, Karen, Zacharias, Wolfgang

Journal:

International Journal of Oncology

Year:

2005

Language:

english

File:

PDF, 3.07 MB

english, 2005

26

Optical Imaging of Drug-Induced Metabolism Changes in Murine and Human Pancreatic Cancer Organoids Reveals Heterogeneous Drug Response

Walsh, Alex J., Castellanos, Jason A., Nagathihalli, Nagaraj S., Merchant, Nipun B., Skala, Melissa C.

Journal:

Year:

2016

Language:

english

File:

PDF, 628 KB

english, 2016

27

Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer

Nagathihalli, Nagaraj S, Castellanos, Jason, Lamichhane, Purushottam, Messaggio, Fanuel, Shi, Chanjuan, Dai, Xizi, Rai, Priyamvada, Chen, Xi, VanSaun, Michael N., Merchant, Nipun B

Journal:

Cancer Research

Year:

2018

Language:

english

File:

PDF, 10.34 MB

english, 2018

28

Emerging targets in pancreatic cancer: epithelial–mesenchymal transition and cancer stem cells

Nagathihalli, Nagaraj, Castellanos, Jason, Merchant,

Journal:

OncoTargets and Therapy

Year:

2013

Language:

english

File:

PDF, 1.12 MB

english, 2013

29

Src-mediated regulation of E-cadherin and EMT in pancreatic cancer

Nagathihalli, Nagaraj, S

Journal:

Frontiers in Bioscience

Year:

2012

Language:

english

File:

PDF, 412 KB

english, 2012

30

Loss of Transforming Growth Factor Beta/SMAD Function Induces Interleukin1α to Mediate Epithelial-to-Mesenchymal Transition in Pancreatic Cancer

Dosch, Austin R., Messaggio, Fanuel, Gaidarski, Alexander, Dai, Xizi, VanSaun, Michael N., Nagathihalli, Nagaraj, Merchant, Nipun B.

Journal:

Journal of the American College of Surgeons

Year:

2018

Language:

english

File:

PDF, 347 KB

english, 2018

31

Combined Src/EGFR Inhibition Targets STAT3 Signaling and Induces Stromal Remodeling to Improve Survival in Pancreatic Cancer

Dosch, Austin R., Dai, Xizi, Reyzer, Michelle L., Mehra, Siddharth, Srinivasan, Supriya, Willobee, Brent A., Kwon, Deukwoo, Kashikar, Nilesh, Caprioli, Richard, Merchant, Nipun B., Nagathihalli, Nagar

Journal:

Molecular Cancer Research

Year:

2020

Language:

english

File:

PDF, 1.45 MB

english, 2020

32

Targeting the Fibroinflammatory Stroma Through Interleukin-1 Inhibition to Improve the Response to Chemotherapy in Pancreatic Cancer

Dosch, Austin R., Singh, Samara, Dai, Xizi, Mehra, Siddharth, Willobee, Brent, Srinivasan, Supriya, Bianchi, Anna, Datta, Jashodeep, Nagathihalli, Nagaraj, Merchant, Nipun B.

Journal:

Journal of the American College of Surgeons

Year:

2020

File:

PDF, 160 KB

2020